The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 157, 2184-2189, Copyright © 1983 by Rockefeller University Press

ARTICLES

Deficiency in suppressor T cell activity in aged animals. Reconstitution of this activity by interleukin 2

ML Thoman and WO Weigle

Spleen cells derived from aged (30 mo) C57Bl/6 mice are shown to be deficient in the ability to generate suppressor cell activity in vitro. The addition of IL-2 to cultures containing aged cells restores this function to a large extent.
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