Journal of Experimental Medicine, Vol 157, 1354-1359, Copyright © 1983 by Rockefeller University Press
Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection
JW Streilein and PR Bergstresser
Hapten-immune mice are capable of rejecting syngeneic skin grafts that are
derivatized with the relevant hapten, but only if the hapten is applied
while the graft is "healing in." This model system was used to demonstrate
that the hapten-specific immune effectors responsible for rejection are
restricted by H-2 determinants of the recipient. Thus, haptens can be used
in vivo as surrogate transplantation antigens for the study of
immunopathogenic mechanisms in transplantation immunity.
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