Human B cell variants immunoselected against a single Ia antigen subset have lost expression of several Ia antigen subsets

doi:10.1084/jem.157.3.1053

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Human B cell variants immunoselected against a single Ia antigen subset have lost expression of several Ia antigen subsets

RS Accolla

Two monoclonal antibodies, D1-12 and BT 2.2, recognizing two distinct subsets of human Ia molecules, NG1 and NG2, respectively, present in all individuals irrespective of their HLA-DR phenotype, have been used to immunoselect cell variants from the lymphoblastoid cell line Raji. Results showed that, irrespective of the monoclonal antibody used for immunoselection, the cell variants analyzed in this study had lost the expression of both D1-12-and BT 2.2-specific antigenic determinants. Moreover, the expression of antigenic determinants specific for a third family of Ia molecules, the DC-1 subset, were also lost in the cell variants. In contrast, expression of HLA A, B, and C common structures, as recognized by the W6.32 monoclonal antibody, as well as expression of surface immunoglobulins, were not affected. Possible mechanisms inducing such a coordinate loss of expression of several families of human Ia molecules are discussed.
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Nagarajan, U. M., Bushey, A., Boss, J. M. (2002). Modulation of Gene Expression by the MHC Class II Transactivator. J. Immunol. 169: 5078-5088 [Abstract] [Full Text]
Giguere, J.-F., Paquette, J.-S., Bounou, S., Cantin, R., Tremblay, M. J. (2002). New Insights into the Functionality of a Virion-Anchored Host Cell Membrane Protein: CD28 Versus HIV Type 1. J. Immunol. 169: 2762-2771 [Abstract] [Full Text]
Hetz, C., Bono, M. R., Barros, L. F., Lagos, R. (2002). Microcin E492, a channel-forming bacteriocin from Klebsiella pneumoniae, induces apoptosis in some human cell lines. Proc. Natl. Acad. Sci. USA 99: 2696-2701 [Abstract] [Full Text]
Nagarajan, U. M., Lochamy, J., Chen, X., Beresford, G. W., Nilsen, R., Jensen, P. E., Boss, J. M. (2002). Class II Transactivator Is Required for Maximal Expression of HLA-DOB in B Cells. J. Immunol. 168: 1780-1786 [Abstract] [Full Text]
Cressman, D. E., O'Connor, W. J., Greer, S. F., Zhu, X.-S., Ting, J. P.-Y. (2001). Mechanisms of Nuclear Import and Export That Control the Subcellular Localization of Class II Transactivator. J. Immunol. 167: 3626-3634 [Abstract] [Full Text]
Sisk, T. J., Roys, S., Chang, C.-H. (2001). Self-Association of CIITA and Its Transactivation Potential. Mol. Cell. Biol. 21: 4919-4928 [Abstract] [Full Text]
Janz, A., Oezel, M., Kurzeder, C., Mautner, J., Pich, D., Kost, M., Hammerschmidt, W., Delecluse, H.-J. (2000). Infectious Epstein-Barr Virus Lacking Major Glycoprotein BLLF1 (gp350/220) Demonstrates the Existence of Additional Viral Ligands. J. Virol. 74: 10142-10152 [Abstract] [Full Text]
Hake, S. B., Masternak, K., Kammerbauer, C., Janzen, C., Reith, W., Steimle, V. (2000). CIITA Leucine-Rich Repeats Control Nuclear Localization, In Vivo Recruitment to the Major Histocompatibility Complex (MHC) Class II Enhanceosome, and MHC Class II Gene Transactivation. Mol. Cell. Biol. 20: 7716-7725 [Abstract] [Full Text]
Masternak, K., Muhlethaler-Mottet, A., Villard, J., Zufferey, M., Steimle, V., Reith, W. (2000). CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex. Genes Dev. 14: 1156-1166 [Abstract] [Full Text]
Brickey, W. J., Wright, K. L., Zhu, X.-S., P.-Y. Ting, J. (1999). Analysis of the Defect in IFN-{gamma} Induction of MHC Class II Genes in G1B Cells: Identification of a Novel and Functionally Critical Leucine-Rich Motif (62-LYLYLQL-68) in the Regulatory Factor X 5 Transcription Factor. J. Immunol. 163: 6622-6630 [Abstract] [Full Text]
Wahlsten, J. L., Mills, C. D., Ramakrishnan, S. (1998). Antitumor Response Elicited by a Superantigen- Transmembrane Sequence Fusion Protein Anchored onto Tumor Cells. J. Immunol. 161: 6761-6767 [Abstract] [Full Text]
Sartoris, S., Valle, M. T., Barbaro, A. D. L., Tosi, G., Cestari, T., D'Agostino, A., Megiovanni, A. M., Manca, F., Accolla2, R. S. (1998). HLA Class II Expression in Uninducible Hepatocarcinoma Cells After Transfection of AIR-1 Gene Product CIITA: Acquisition of Antigen Processing and Presentation Capacity. J. Immunol. 161: 814-820 [Abstract] [Full Text]
Wahlsten, J. L., Ramakrishnan, S. (1998). Separation of Function Between the Domains of Toxic Shock Syndrome Toxin-1. J. Immunol. 160: 854-859 [Abstract] [Full Text]
Cantin, R., Fortin, J.-F., Lamontagne, G., Tremblay, M. (1997). The Acquisition of Host-Derived Major Histocompatibility Complex Class II Glycoproteins by Human Immunodeficiency Virus Type 1�Accelerates the Process of Virus Entry and Infection in Human T-Lymphoid Cells. Blood 90: 1091-1100 [Abstract] [Full Text]
Ravanel, K., Castelle, C., Defrance, T., Wild, T. F., Charron, D., Lotteau, V., Rabourdin-Combe, C. (1997). Measles Virus Nucleocapsid Protein Binds to Fcgamma RII and Inhibits Human B Cell Antibody Production. J. Exp. Med. 186: 269-278 [Abstract] [Full Text]
Scholl, T., Mahanta, S. K., Strominger, J. L. (1997). Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA�and�RFX5. Proc. Natl. Acad. Sci. USA 94: 6330-6334 [Abstract] [Full Text]
Douhan, J. III, Lieberson, R., Knoll, J. H.M., Zhou, H., Glimcher, L. H. (1997). An Isotype-specific Activator of Major Histocompatibility Complex (MHC) Class II Genes That Is Independent of Class II Transactivator. J. Exp. Med. 185: 1885-1895 [Abstract] [Full Text]
Chin, K.-C., Li, G. G.-X., Ting, J. P.-Y. (1997). Importance of acidic, proline/serine/threonine-rich, and GTPbinding regions in the major histocompatibility complex class II transactivator: Generation of�transdominant-negative�mutants. Proc. Natl. Acad. Sci. USA 94: 2501-2506 [Abstract] [Full Text]
Steimle, V, Durand, B, Barras, E, Zufferey, M, Hadam, M R, Mach, B, Reith, W (1995). A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome).. Genes Dev. 9: 1021-1032 [Abstract]
Kara, C., Glimcher, L. (1991). In vivo footprinting of MHC class II genes: bare promoters in the bare lymphocyte syndrome. Science 252: 709-712 [Abstract]
Mollick, J., Cook, R., Rich, R. (1989). Class II MHC molecules are specific receptors for staphylococcus enterotoxin A. Science 244: 817-820 [Abstract]
Nickerson, K., Sisk, T. J., Inohara, N., Yee, C. S. K., Kennell, J., Cho, M.-C., Yannie, P. J. II, Nunez, G., Chang, C.-H. (2001). Dendritic Cell-specific MHC Class II Transactivator Contains a Caspase Recruitment Domain That Confers Potent Transactivation Activity. J. Biol. Chem. 276: 19089-19093 [Abstract] [Full Text]