The Journal of Experimental Medicine
Torrey Pines Biolabs
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Journal of Experimental Medicine, Vol 157, 795-800, Copyright © 1983 by Rockefeller University Press

ARTICLES

Fine specificity of idiotope suppression in the A/J anti- azophenylarsonate response

TL Rothstein, MN Margolies, ML Gefter and A Marshak-Rothstein

Two hapten-inhibitable murine monoclonal antiidiotopic antibodies identified two idiotopes expressed by the heavy chain of hybridoma protein 36-65, whose amino acid sequence is encoded in the germ line of A/J mice. Among cross-reactive idiotype-positive hybridoma proteins and p-azophenylarsonate-immune antibodies, the two idiotopes were not always expressed together; some diversified antibodies expressed one idiotope without the other. Suppression that was induced by the two antiidiotopes was idiotope specific and corresponded to the fine specificities of these two reagents.
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