Multiple human beta interferon genes

doi:10.1084/jem.156.3.744

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Multiple human beta interferon genes

AD Sagar, PB Sehgal, DL Slate and FH Ruddle

Analysis of human beta interferon (IFN) mRNA preparations obtained from poly(I) . poly (C)-induced human diploid fibroblasts (FS-4) and from several similarly induced human-mouse somatic cell hybrids by electrophoresis through agarose-CH3HgOH tube gels led to the detection of at least five translationally active human IFN-beta mRNA species. The results obtained are consistent with the existence of IFN-beta genes on different human chromosomes. Marked cell-dependent variability in the expression of these IFN mRNA species was observed.
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Sehgal, P., May, L., Tamm, I, Vilcek, J (1987). Human beta 2 interferon and B-cell differentiation factor BSF-2 are identical. Science 235: 731-732
Sagar, A., Sehgal, P., May, L., Inouye, M, Slate, D., Shulman, L, Ruddle, F. (1984). Interferon-beta-related DNA is dispersed in the human genome. Science 223: 1312-1315 [Abstract]