Journal of Experimental Medicine, Vol 156, 294-299, Copyright © 1982 by Rockefeller University Press
Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes
LA Sherman
The specificity repertoire of H-2Kb-specific cytolytic T lymphocytes (CTL)
has been examined in B10.D2,BALB/c, and the allotype congenic line CB-20.
Comparing their expression of recurrent specificities that serve as markers
for the repertoire of each strain indicates that the CTL repertoire of
B10.D2 (Ighb) and BALB/c (Igha) differ extensively. In contrast, the
repertoires expressed by B10.D2 and CB-20 (Ighb) are essentially identical
with respect to their expression of the same recurrent specificities. Taken
together with results previously obtained, it is concluded that both major
histocompatibility complex and Igh-linked genes affect the CTL specificity
repertoire.