The Journal of Experimental Medicine
Keystone Symposia
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Journal of Experimental Medicine, Vol 155, 1100-1107, Copyright © 1982 by Rockefeller University Press

ARTICLES

Definition of T cell idiotypes using anti-idiotypic antisera produced by immunization with T cell clones

AJ Infante, PD Infante, S Gillis and CG Fathman

Alloreactive T cell clones with distinct specificities were used to raise anti-idiotypic antisera via an F1 anti-(parent anti-F1) protocol. Antisera were raised that could stimulate the proliferation of the appropriate T cell clone, but not other clones. The active fraction of the antisera for T cell proliferation was immunoglobulin. In addition to proliferation, an anti-idiotypic antiserum could induce the appropriate T cell clone to secrete substantial amounts of interleukin 2 (IL-2). Production of IL-2 appeared independent of the involvement of accessory cells. These accessory cells may be unnecessary for IL-2 production in our assay, or their effect may be produced by anti- idiotype. Thus, anti-idiotype may provide two or more specific T cell signals.
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