The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 155, 1075-1085, Copyright © 1982 by Rockefeller University Press

ARTICLES

Murine interstitial nephritis. I. Analysis of disease susceptibility and its relationship of pleiomorphic gene products defining both immune- response genes and a restrictive requirement for cytotoxic T cells at H- 2K

EG Neilson and SM Phillips

Anti-tubular basement membrance (alpha TBM) disease-producing interstitial nephritis in mice is not dependent on the generation of alpha TBM antibodies. Susceptibility seems to be defined by very private specificities in H-2K. These specificities are pleiomorphic, providing both immune-response genes and identity restrictions for cytotoxic effector functions expressed by a Thy-1.2+, Lyt-2,3+ T cell. These studies establish a role for T cells in the pathogenesis in interstitial nephritis as well as providing further evidence for the role of H-2K in the expression of an autoimmune disease.
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