The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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Journal of Experimental Medicine, Vol 155, 611-616, Copyright © 1982 by Rockefeller University Press

ARTICLES

Ubiquitous nonimmunoglobulin p-azobenzenearsonate-binding molecules from lymphoid cells

AF Clark and JD Capra

A ubiquitous nonimmunoglobulin molecule that binds p-azobenzenearsonate (ABA) has been detected in the cytoplasm of several murine cell lines, including T cell hybridomas as well as in normal liver and spleen. Similar to many recently described antigen-specific T cell factors, this ABA-binding protein has a 62,000 mol wt, and, when analyzed by direct binding, the molecule reacts with several different rabbit anti- idiotypic antisera specific to the ABA system. The presence of this antigen-specific, "idiotype positive" molecule in many different cells indicates that it is not an important immunoregulatory molecule.
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