Journal of Experimental Medicine, Vol 155, 155-167, Copyright © 1982 by Rockefeller University Press

ARTICLES

Identification of a hemagglutinin-specific idiotype associated with reovirus recognition shared by lymphoid and neural cells

JT Nepom, HL Weiner, MA Dichter, M Tardieu, DR Spriggs, CF Gramm, ML Powers, BN Fields and MI Greene

A xenogeneic antiserum raised to antireovirus immunoglobulin was used to define an idiotypic determinant present on antibodies to reovirus type 3 hemagglutinin. The same idiotype was identified on nonimmune lymphoid cells and on neuronal cells that specifically bind the hemagglutinin of type 3 reovirus. This idiotypic determinant, called Id3, is shared by (a) a monoclonal antibody to the neutralization site of hemagglutinin from type 3 reovirus; (b) BALB/c serum antibodies to the hemagglutinin of reovirus type 3; (c) R1.1, a murine thymoma cell line that binds reovirus type 3; (d) primary cultures of murine neuronal cells. The presence of an idiotype shared by antihemagglutinin antibodies and by structures on nonlymphoid cells suggests a general relationship between disparate receptors that recognize a common determinant. Furthermore, this suggests a novel approach for the study of viral receptor interactions and for analysis of mechanisms of autoimmune responses.
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This article has been cited by other articles:

• Meite, M., Léonard, S., Idrissi, M. E. A. E., Izui, S., Masson, P. L., Coutelier, J.-P. (2000). Exacerbation of Autoantibody-Mediated Hemolytic Anemia by Viral Infection. J. Virol. 74: 6045-6049 [Abstract] [Full Text]  
• Spriggs, D., Bronson, R., Fields, B. (1983). Hemagglutinin variants of reovirus type 3 have altered central nervous system tropism. Science 220: 505-507 [Abstract]  

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