Journal of Experimental Medicine, Vol 155, 126-139, Copyright © 1982 by Rockefeller University Press
Two distinct allotypic determinants on the antigen-specific suppressor and enhancing T cell factors that are encoded by genes linked to the immunoglobulin heavy chain locus
T Tokuhisa and M Taniguchi
The alloantiserum was raised in BALB/c (H-2d, Igh-1a) mice hyperimmunized
with spleen cells of Igh allotype congenic mice, CB-20 (H-2d, Igh-1b). It
was found to define the new allotypic determinants (distinct from B cell
Igh constant region determinants: Igh allotype) expressed only on a small
population of T cells belonging to the Thy-1 dull-stained Lyt-2- or Lyt-2+
population of Igh-1b mice. Genes coding for the determinants were shown to
be accommodated somewhere in the right side of the Igh variable region gene
(Igh-V) cluster, as the antibody activity was completely absorbed with
BAB-14 thymocytes. It was also demonstrated that the products detected by
the antiserum represent the allotypic determinants (probably constant
region determinants) on the antigen-binding moiety of the antigen-specific
augmenting (TaF) and suppressor (TsF) T cell factors. Moreover,
determinants on TsF were found to be distinct from those on TaF. Therefore,
it can be suggested that the two genes coding for the T cell
allodeterminants (distinct from those of the B cell Igh) are located in the
right side of the B cell Igh-V on the 12th chromosome, and that both encode
the antigen-recognition units of the functionally distinct T cell factors.
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