Type II collagen-induced arthritis in rats. Passive transfer with serum and evidence that IgG anticollagen antibodies can cause arthritis

doi:10.1084/jem.155.1.1

This Article

Full Text (PDF)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JEM

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Stuart, J. M.

Articles by Kang, A. H.

Search for Related Content

PubMed

PubMed Citation

Articles by Stuart, J. M.

Articles by Kang, A. H.

Pubmed/NCBI databases

Medline Plus Health Information
Substance via MeSH
Arthritis
Joint Disorders

Social Bookmarking

What's this?

ARTICLES

Type II collagen-induced arthritis in rats. Passive transfer with serum and evidence that IgG anticollagen antibodies can cause arthritis

JM Stuart, MA Cremer, AS Townes and AH Kang

We have found that serum from rats with type II collagen-induced arthritis, when fractionated with 50% ammonium sulfate and concentrated, would transfer arthritis to nonimmunized recipients. The arthritis in recipients developed within 18-72 h and displayed all of the major histopathologic characteristics of the early lesion in immunized animals but was transient and less severe. Although consideration was given to the possibility that a circulating immune complex was involved, no evidence of such a complex was detected. Further fractionation of the serum yielded an IgG anticollagen antibody that was fully active in transferring disease. The antibody's reaction was inhibited by the native bovine type II collagen used for immunization of donors and the antibody strongly cross-reacted with homologous type II collage but not with denatured collagen. These studies demonstrate that arthritis in rats can be induced with anti- type II collagen antibodies and suggest that an autoimmune process is involved. Because antibodies to collagen have also been detected in human rheumatic diseases, further investigation of the characteristics of collagen antibodies capable of inducing arthritis seems warranted.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Kochetkova, I., Trunkle, T., Callis, G., Pascual, D. W. (2008). Vaccination without Autoantigen Protects against Collagen II-Induced Arthritis via Immune Deviation and Regulatory T Cells. J. Immunol. 181: 2741-2752 [Abstract] [Full Text]
Banda, N. K., Takahashi, K., Wood, A. K., Holers, V. M., Arend, W. P. (2007). Pathogenic Complement Activation in Collagen Antibody- Induced Arthritis in Mice Requires Amplification by the Alternative Pathway. J. Immunol. 179: 4101-4109 [Abstract] [Full Text]
Zhang, M., Ko, K.-H., Lam, Q. L. K., Lo, C. K. C., Srivastava, G., Zheng, B., Lau, Y.-L., Lu, L. (2005). Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis. Int Immunol 17: 1081-1092 [Abstract] [Full Text]
Yoo, S.-A., Bae, D.-G., Ryoo, J.-W., Kim, H.-R., Park, G.-S., Cho, C.-S., Chae, C.-B., Kim, W.-U. (2005). Arginine-Rich Anti-Vascular Endothelial Growth Factor (Anti-VEGF) Hexapeptide Inhibits Collagen-Induced Arthritis and VEGF-Stimulated Productions of TNF-{alpha} and IL-6 by Human Monocytes. J. Immunol. 174: 5846-5855 [Abstract] [Full Text]
Dalbeth, N., Edwards, J., Fairchild, S., Callan, M., Hall, F. C. (2005). The non-thiol angiotensin-converting enzyme inhibitor quinapril suppresses inflammatory arthritis. Rheumatology (Oxford) 44: 24-31 [Abstract] [Full Text]
Cremer, M. A., Ye, X. J., Myers, L. K., Brand, D. D., Rosloniec, E. F., Kang, A. H. (2004). T Cell Immunity to Type II Collagen in the Biobreeding Rat: The Identification and Characterization of RT1u-Restricted T Cell Epitopes on {alpha}1(II). J. Immunol. 173: 1795-1801 [Abstract] [Full Text]
Wipke, B. T., Wang, Z., Nagengast, W., Reichert, D. E., Allen, P. M. (2004). Staging the Initiation of Autoantibody-Induced Arthritis: A Critical Role for Immune Complexes. J. Immunol. 172: 7694-7702 [Abstract] [Full Text]
Hansson, A.-S., Johannesson, M., Svensson, L., Nandakumar, K. S., Heinegard, D., Holmdahl, R. (2004). Relapsing Polychondritis, Induced in Mice with Matrilin 1, Is an Antibody- and Complement-Dependent Disease. Am. J. Pathol. 164: 959-966 [Abstract] [Full Text]
Nandakumar, K. S., Svensson, L., Holmdahl, R. (2003). Collagen Type II-Specific Monoclonal Antibody-Induced Arthritis in Mice: Description of the Disease and the Influence of Age, Sex, and Genes. Am. J. Pathol. 163: 1827-1837 [Abstract] [Full Text]
Banda, N. K., Kraus, D. M., Muggli, M., Bendele, A., Holers, V. M., Arend, W. P. (2003). Prevention of Collagen-Induced Arthritis in Mice Transgenic for the Complement Inhibitor Complement Receptor 1-Related Gene/Protein y. J. Immunol. 171: 2109-2115 [Abstract] [Full Text]
Brand, D. D., Myers, L. K., Whittington, K. B., Latham, K. A., Stuart, J. M., Kang, A. H., Rosloniec, E. F. (2002). Detection of Early Changes in Autoimmune T Cell Phenotype and Function Following Intravenous Administration of Type II Collagen in a TCR-Transgenic Model. J. Immunol. 168: 490-498 [Abstract] [Full Text]
Wipke, B. T., Allen, P. M. (2001). Essential Role of Neutrophils in the Initiation and Progression of a Murine Model of Rheumatoid Arthritis. J. Immunol. 167: 1601-1608 [Abstract] [Full Text]
Wernhoff, P., Unger, C., Bajtner, E., Burkhardt, H., Holmdahl, R. (2001). Identification of conformation-dependent epitopes and V gene selection in the B cell response to type II collagen in the DA rat. Int Immunol 13: 909-919 [Abstract] [Full Text]
Yoshino, S., Sasatomi, E., Mori, Y., Sagai, M. (1999). Oral Administration of Lipopolysaccharide Exacerbates Collagen-Induced Arthritis in Mice. J. Immunol. 163: 3417-3422 [Abstract] [Full Text]
Yoshino, S., Sagai, M. (1999). Enhancement of Collagen-Induced Arthritis in Mice by Diesel Exhaust Particles. J. Pharmacol. Exp. Ther. 290: 524-529 [Abstract] [Full Text]
Corthay, A., Johansson, A., Vestberg, M., Holmdahl, R. (1999). Collagen-induced arthritis development requires {alpha}{beta} T cells but not {gamma}{delta} T cells: studies with T cell-deficient (TCR mutant) mice. Int Immunol 11: 1065-1073 [Abstract] [Full Text]
Plows, D., Kontogeorgos, G., Kollias, G. (1999). Mice Lacking Mature T and B Lymphocytes Develop Arthritic Lesions after Immunization with Type II Collagen. J. Immunol. 162: 1018-1023 [Abstract] [Full Text]
Rosloniec1, E. F., Brand, D. D., Myers, L. K., Esaki, Y., Whittington, K. B., Zaller, D. M., Woods, A., Stuart, J. M., Kang, A. H. (1998). Induction of Autoimmune Arthritis in HLA-DR4 (DRB1*0401) Transgenic Mice by Immunization with Human and Bovine Type II Collagen. J. Immunol. 160: 2573-2578 [Abstract] [Full Text]
Yoshino, S. (1998). Treatment with an Anti-IL-4 Monoclonal Antibody Blocks Suppression of Collagen-Induced Arthritis in Mice by Oral Administration of Type II Collagen. J. Immunol. 160: 3067-3071 [Abstract] [Full Text]
Rosloniec, E. F., Brand, D. D., Myers, L. K., Whittington, K. B., Gumanovskaya, M., Zaller, D. M., Woods, A., Altmann, D. M., Stuart, J. M., Kang, A. H. (1997). An HLA-DR1 Transgene Confers Susceptibility to Collagen-induced Arthritis Elicited with Human Type II Collagen. J. Exp. Med. 185: 1113-1122 [Abstract] [Full Text]
PEREIRA, R. S., BLACK, C. M., TURNER, S. M., SPENCER, J. D. (1986). Antibodies to Collagen Types I-VI in Dupuytren's Contracture. J Hand Surg Eur Vol 11: 58-60 [Abstract]
Holoshitz, J, Naparstek, Y, Ben-Nun, A, Cohen, I. (1983). Lines of T lymphocytes induce or vaccinate against autoimmune arthritis. Science 219: 56-58 [Abstract]