The Journal of Experimental Medicine
3rd Skeletal Biology and Medicine Symposium
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Journal of Experimental Medicine, Vol 152, 458-462, Copyright © 1980 by Rockefeller University Press

ARTICLES

Evidence that endogenous ecotropic virus is not expressed in AKR thymic lymphoid cells of chimeric hosts

KJ Blank and T Pincus

AKR/J thymocytes derived from fetal liver cells do not produce virus when they differentiate in lethally irradiated B10.K mice, whereas spleen and bone marrow cells are virus producers. In contrast, B10.K thymocytes that differentiate in lethally irradiated AKR mice become virus producers. These results suggest that infection of the thymus in AKR mice is initiated in thymic stromal cells.
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