Journal of Experimental Medicine, Vol 152, 452-457, Copyright © 1980 by Rockefeller University Press

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IgA-dependent, monocyte-mediated, antibacterial activity

GH Lowell, LF Smith, JM Griffiss and BL Brandt

IgA purified from the sera of patients convalescing from disseminated group C meningococcal disease induced human monocyte-mediated anti- meningococcal activity in vitro in the absence of complement. Both IgA- and IgG-dependent activity were directed against the group C meningococcal polysaccharide (Csss) capsule. The amount of IgA that was effective bound less than 1 ng of Csss. Antibacterial activity was dependent upon the length and the temperature of the test incubation and on the concentration of monocytes. The implications of this mechanism for local cell-mediated antibacterial immunity are discussed.
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