The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 151, 1563-1568, Copyright © 1980 by Rockefeller University Press


ARTICLES

Murine pancreatic beta-cells express H-2K and H-2D but not Ia antigens

D Faustman, V Hauptfeld, JM Davie, PE Lacy and DC Shreffler

Direct microcytotoxicity testing and absorption analyses were employed to determine whether H-2K, H-2D, and Ia antigens are present on murine islet of Langerhans cells. Products of the H-2K and H-2D loci were found on beta-cells from three different mouse strains, but I-region (Ia) antigens were not detected. The absence of Ia gene products from islet cells may be of importance in explaining the survival of islet allografts across major histocompatibility barriers.
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