Journal of Experimental Medicine, Vol 151, 1386-1397, Copyright © 1980 by Rockefeller University Press

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Dissection of the B10.D2 anti-H-2Kb cytolytic T lymphocyte receptor repertoire

LA Sherman

The B10.D2 cytolytic T lymphocyte (CTL) receptor repertoire specific for the H-2Kb alloantigen has been studied by determining the reactivity patterns of monoclonal CTL against a panel of seven different H-2Kb mutants. The repertoire is extremely diverse and contains a minimum of approximately 50 different specificities against unique antigenic determinants on the H-2Kb molecule. Each specificity appears at a maximum frequency of 1 in 18,000 CTL precursors. These studies have also served to dissect the antigenic composition of the H- 2Kb molecule. Very few CTL clonotypes share recognition of all the mutants, thereby indicating the lack of conservation of a b-type antigenic region. In addition, the degree to which each mutant shares antigenic determinants with the standard H-2Kb molecule has been determined.
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This article has been cited by other articles:

• Morgan, D. J., Nugent, C. T., Raveney, B. J. E., Sherman, L. A. (2004). In a Transgenic Model of Spontaneous Autoimmune Diabetes, Expression of a Protective Class II MHC Molecule Results in Thymic Deletion of Diabetogenic CD8+ T Cells. J. Immunol. 172: 1000-1008 [Abstract] [Full Text]  
• Hernandez, J., Ko, A., Sherman, L. A. (2001). CTLA-4 Blockade Enhances the CTL Responses to the p53 Self-Tumor Antigen. J. Immunol. 166: 3908-3914 [Abstract] [Full Text]  

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