T200 cell surface glycoprotein of the mouse. Polymorphism defined by the Ly-5 system of alloantigens

doi:10.1084/jem.151.5.1311

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T200 cell surface glycoprotein of the mouse. Polymorphism defined by the Ly-5 system of alloantigens

MB Omary, IS Trowbridge and MP Scheid

The cell line BW5147, and a mutant T200-negative cell line derived from BW5147, were studed by immunoprecipitation and peptide mapping, with xenogeneic monoclonal anti-T200 serum and with Ly-5 alloantiserum. It appears that the Ly-5 system defines a structural polymorphism of the cell surface glycoprotein T200, and that the monoclonal anti-T200 serum defines a feature of T200 that is common to mice of both Ly-5a and Ly- 5b genotypes and may be invariable in the species.
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