Journal of Experimental Medicine, Vol 150, 729-753, Copyright © 1979 by Rockefeller University Press
A transmissible avian neoplasm. (Sarcoma of the common fowl) by Peyton Rous, M.D., Experimental Medicine for Sept. 1, 1910, vol. 12, pp.696- 705
P Rous
In this paper is reported the first avian tumor that has proved
transplantable to other individuals. It is a spindle-celled sarcoma of the
hen, which thus far has been propagated into its fourth tumor generation.
This was accomplished by the use of fowls of pure blood from the small,
intimately related stock in which the growth occurred. Market-bought fowls
of similar variety have shown themselves insusceptible, as have fowls of
mixed breed, pigeons and guinea-pigs. The percentage of successful
transplantations has been small, but in the individuals developing a tumor
its growth has been fairly rapid. Young chickens are more susceptible than
adults. The reinoculation of negative fowls has never resulted in a growth.
Throughout, the sarcoma has remained true to type. It is infiltrative and
destructive. Metastasis has been observed once (to the heart). Experiments
to determine whether the growth may be transmitted by cell-fragments have
not yet been made. Repeated bacteriological examinations have yielded
negative results. In its general behavior, so far as tested, this avian
tumor closely resembles the typical mammalian neoplasms that are
transplantable.
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