Journal of Experimental Medicine, Vol 150, 646-652, Copyright © 1979 by Rockefeller University Press
Genetic control of the immune response to collagen. II. Antibody responses produced in fetal liver restored radiation chimeras and thymus reconstituted F1 hybrid nude mice
SM Hedrick and J Watson
The level of antibody produced in response to calf skin collagen in mice is
influenced by genes which are closely linked to the I region of the H-2
major histocompatibility complex. This influence is shown to be expressed
during lymphoid maturation by testing the antibody responsiveness to
collagen in two types of chimeric mice. First, high responder and low
responder parental strain mice were lethally irradiated and restored with
fetal liver cells from (high X low responder) F1 mice. These F1 leads to
parent chimeras exhibited an immune response phenotype characteristic of
the irradiated parental strain animals, establishing that H-2 determinants
of the host affect antigen responsiveness. Second, (high X low responder)
F1 congenitally athymic (nude) mice were restored with fetal thymus
transplants from either high or low responder parental strain mice. After a
period of maturation these mice were shown to be competent for a
T-dependent IgG response to SRBC. The responsiveness to collagen in these
mice was characteristic of the parental strain thymus donors, indicating
that the expression of H-2 determinants in thymic tissue during lymphoid
maturation influences the antibody response phenotype expressed by mice.
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