The Journal of Experimental Medicine
Randox clinical diagnostic solutions
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Journal of Experimental Medicine, Vol 149, 1238-1253, Copyright © 1979 by Rockefeller University Press

ARTICLES

Localization of H-2 antigens on mouse trophoblast cells

S Chatterjee-Hasrouni and PK Lala

The presence of H-2 antigens of the paternal and maternal haplotypes on mouse trophoblast cells was examined at several stages of pregnancy by using a sensitive immunolabeling technique followed by quantitative radioautography. Results revealed the presence of H-2 antigens (determined by the K or D loci) of both parental haplotypes on the F1 trophoblast cells. At 14-16 d of gestation, the antigen density was equivalent to that on adult thymocytes and there was a further 50% increase on day 18. H-2 antigens of both parental haplotypes are also found to be expressed on 11-13 d trophoblast cells.
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