Association of circulating retroviral gp70-anti-gp70 immune complexes with murine systemic lupus erythematosus

doi:10.1084/jem.149.5.1099

3rd Skeletal Biology and Medicine Symposium

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Izui, S.
	Articles by Dixon, F. J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Izui, S.
	Articles by Dixon, F. J.


Social Bookmarking

	What's this?

ARTICLES

Association of circulating retroviral gp70-anti-gp70 immune complexes with murine systemic lupus erythematosus

S Izui, PJ McConahey, AN Theofilopoulos and FJ Dixon

Endogenous retroviral gp70 was investigated as a participant in the pathogenesis of a lupus-like disease that spontaneously develops in four kinds of mice (NZB, NZB x W MRL/1, and male BXSB). Sera from these strains contain a heavy form of gp 70 that varies in sedimentation rates from 9S to 19S in sucrose density gradient analysis and appears with the onset of disease and persists throughout its course. Immunologically normal strains of mice do not develop rapidly sedimenting gp70 by 8-10 mo of life. The fact that the heavy gp70 is selectively absorbed with anti-IgG antibodies or with Staphylococcus aureus protein A suggests that it is complexed with antibodies. The incidence and quantities of these gp70 ICs rise with the progression of disease in all strains with lupus. These findings suggest that Ig- complexed heavy gp70 may be involved in the pathogenesis of glomerulonephritis of mice with SLE.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Borel, P., Benkhoucha, M., Weber, M. S., Zamvil, S. S., Santiago-Raber, M.-L., Lalive, P. H. (2008). Glatiramer acetate treatment does not modify the clinical course of (NZB x BXSB)F1 lupus murine model. Int Immunol 20: 1313-1319 [Abstract] [Full Text]
Baudino, L., Yoshinobu, K., Morito, N., Kikuchi, S., Fossati-Jimack, L., Morley, B. J., Vyse, T. J., Hirose, S., Jorgensen, T. N., Tucker, R. M., Roark, C. L., Kotzin, B. L., Evans, L. H., Izui, S. (2008). Dissection of Genetic Mechanisms Governing the Expression of Serum Retroviral gp70 Implicated in Murine Lupus Nephritis. J. Immunol. 181: 2846-2854 [Abstract] [Full Text]
Rankin, J., Boyle, J. J., Rose, S. J., Gabriel, L., Lewis, M., Thiruudaian, V., Rogers, N. J., Izui, S., Morley, B. J. (2007). The Bxs6 Locus of BXSB Mice Is Sufficient for High-Level Expression of gp70 and the Production of gp70 Immune Complexes. J. Immunol. 178: 4395-4401 [Abstract] [Full Text]
Kikuchi, S., Fossati-Jimack, L., Moll, T., Amano, H., Amano, E., Ida, A., Ibnou-Zekri, N., Laporte, C., Santiago-Raber, M.-L., Rozzo, S. J., Kotzin, B. L., Izui, S. (2005). Differential Role of Three Major New Zealand Black-Derived Loci Linked with Yaa-Induced Murine Lupus Nephritis. J. Immunol. 174: 1111-1117 [Abstract] [Full Text]
Laporte, C., Ballester, B., Mary, C., Izui, S., Reininger, L. (2003). The Sgp3 Locus on Mouse Chromosome 13 Regulates Nephritogenic gp70 Autoantigen Expression and Predisposes to Autoimmunity. J. Immunol. 171: 3872-3877 [Abstract] [Full Text]
Alexander, J. J., Saxena, A. K., Bao, L., Jacob, A., Haas, M., Quigg, R. J. (2002). Prominent Renal Expression of a Murine Leukemia Retrovirus in Experimental Systemic Lupus Erythematosus. J. Am. Soc. Nephrol. 13: 2869-2877 [Abstract] [Full Text]
Haywood, M. E. K., Vyse, T. J., McDermott, A., Thompson, E. M., Ida, A., Walport, M. J., Izui, S., Morley, B. J. (2001). Autoantigen Glycoprotein 70 Expression Is Regulated by a Single Locus, Which Acts as a Checkpoint for Pathogenic Anti-Glycoprotein 70 Autoantibody Production and Hence for the Corresponding Development of Severe Nephritis, in Lupus-Prone BXSB Mice1. J. Immunol. 167: 1728-1733 [Abstract] [Full Text]
Tucker, R. M., Vyse, T. J., Rozzo, S., Roark, C. L., Izui, S., Kotzin, B. L. (2000). Genetic Control of Glycoprotein 70 Autoantigen Production and Its Influence on Immune Complex Levels and Nephritis in Murine Lupus. J. Immunol. 165: 1665-1672 [Abstract] [Full Text]
Rozzo, S. J., Vyse, T. J., Menze, K., Izui, S., Kotzin, B. L. (2000). Enhanced Susceptibility to Lupus Contributed from the Nonautoimmune C57BL/10, But Not C57BL/6, Genome. J. Immunol. 164: 5515-5521 [Abstract] [Full Text]
Vyse, T. J., Halterman, R. K., Rozzo, S. J., Izui, S., Kotzin, B. L. (1999). Control of separate pathogenic autoantibody responses marks MHC gene contributions to murine lupus. Proc. Natl. Acad. Sci. USA 96: 8098-8103 [Abstract] [Full Text]
Maldonado, M. A., Kakkanaiah, V., MacDonald, G. C., Chen, F., Reap, E. A., Balish, E., Farkas, W. R., Jennette, J. C., Madaio, M. P., Kotzin, B. L., Cohen, P. L., Eisenberg, R. A. (1999). The Role of Environmental Antigens in the Spontaneous Development of Autoimmunity in MRL-lpr Mice. J. Immunol. 162: 6322-6330 [Abstract] [Full Text]
Rozzo, S. J., Vyse, T. J., David, C. S., Palmer, E., Izui, S., Kotzin, B. L. (1999). Analysis of MHC Class II Genes in the Susceptibility to Lupus in New Zealand Mice. J. Immunol. 162: 2623-2630 [Abstract] [Full Text]
Vyse, T. J., Rozzo, S. J., Drake, C. G., Appel, V. B., Lemeur, M., Izui, S., Palmer, E., Kotzin, B. L. (1998). Contributions of Eaz and Ebz MHC Genes to Lupus Susceptibility in New Zealand Mice. J. Immunol. 160: 2757-2766 [Abstract] [Full Text]