Monoclonal cytolytic T-cell lines

doi:10.1084/jem.149.1.273

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Monoclonal cytolytic T-cell lines

PE Baker, S Gillis and KA Smith

Monospecific cloned cytolytic T-lymphocyte lines have been created utilizing T-cell growth factor. The clones were found to retain their cytolytic specificity after prolonged culture and monospecific function was demonstrated by subcloning procedures. Thus, detailed studies of the phenotypic and functional characteristics of monospecific, homogeneous, cytolytic T lymphocytes will now be possible.
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