The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 148, 1620-1627, Copyright © 1978 by Rockefeller University Press

ARTICLES

The induction of virus-specific cytotoxic T lymphocytes with solubilized viral and membrane proteins

R Finberg, M Mescher and SJ Burakoff

Reconstituted membranes were prepared from detergent solubilized P815 (H-2d) tumor cell membranes and solubilized Sendai virus protein. These reconstituted membranes stimulated a virus-specific H-2-restricted secondary CTL response. Stimulating activity was dependent upon the presence of both viral and P815 protein in the same membrane and was restricted to the H-2 specificity present in the reconstituted membrane. Liposomes prepared from solubilized Sendai virus proteins and partially purified H-2 alloantigen also had activity for CTL induction. The results demonstrate the feasibility of using detergent solubilized membrane proteins to study antigen recognition by virus-specific, H-2 restricted cytolytic T lymphocytes.
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