Journal of Experimental Medicine, Vol 148, 1458-1467, Copyright © 1978 by Rockefeller University Press
HLA restriction of human cytotoxic T lymphocytes specific for influenza virus. Poor recognition of virus associated with HLA A2
A McMichael
Cytotoxic T lymphocytes (CTL), specific for influenza A/X31 virus, were
generated from human peripheral blood lymphocytes. These CTL lysed target
cells that were infected with the same virus and that shared HLA A or B
locus antigens. Minimal lysis was observed when HLA-D antigens were shared.
Not all HLA A and B antigens were equally effective. Efficient lysis of
target cells was seen when HLA A1, A3, B7, B8, B27 and BW21 were shared
with the CTL, but when HLA A2 was the only shared antigen lysis was usually
minimal. This deficiency in CTL function associated with HLA A2 was not
absolute. It is suggested that the function of this antigen might be
influenced by other surface molecules on the cell and in particular the
other HLA products.
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