The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 148, 1435-1439, Copyright © 1978 by Rockefeller University Press

ARTICLES

Secondary induction of cytotoxic T lymphocytes with solubilized syngeneic tumor cell plasma membranes

O Alaba and LW Law

Secondary induction of in vitro cytotoxic T lymphocytes in a syngeneic system has been achieved with plasma membrane, both in the particulate and solubilized forms. Both the induction and the lytic phases were shown to be immunologically specific. The effector cells generated were completely susceptible to treatment with anti-theta antibody and complement, suggesting that they are T lymphocytes.
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