The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 148, 619-623, Copyright © 1978 by Rockefeller University Press


ARTICLES

Regulation of cytotoxic T-cell reactivity to syngeneic tumors by the thymus

CL Reinisch and SL Andrew

Adult thymectomy has been shown to result in the enhanced capacity of splenic T cells to respond to and lyse syngeneic tumor cells in vitro. In addition, T cells from thymectomized mice which kill syngeneic tumor cells do not lyse either normal lymphoid or mitogen-stimulated syngeneic lymphoblast target cells. These findings indicate that the thymus exports a subpopulation of T cells sensitive to adult thymectomy which regulates the generation of cytolytic T cells directed against syngeneic tumor cells.
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