Journal of Experimental Medicine, Vol 147, 997-1006, Copyright © 1978 by Rockefeller University Press
Immunosuppressive factors from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10. IV. Lack of strain restrictions among allogeneic, nonresponder donors and recipients
JA Kapp
The synthetic terpolymer of L-glutamic acid60-L-alanine30-L-tyrosine10
(GAT) fails to stimulate development of GAT-specific antibody responses in
nonresponder mice but stimulates development of GAT-specific suppressor T
cells that inhibit the development of normal anti-GAT plaque-forming cell
responses to GAT complexed to methylated bovine serum albumin (MBSA).
Extracts from lymphoid cells of GAT-primed but not control, nonresponder
(DBA/1) mice contain a T-cell factor (GAT- TsF) that also specifically
suppresses responses to GAT-MBSA by normal syngeneic spleen cells. The
experiments reported in this communication demonstrate that: (a) extracts
from all GAT-primed nonresponder mice tested contain GAT-TsF; (b) non-H-2
genes do not restrict the production of GAT-TsF; (c) all nonresponder
strains of mice regardless of their non-H-2 genes are suppressed by GAT-TsF
from all other strains bearing the nonresponder H-2p,q,s haplotypes; (d)
suppression of GAT- MBSA responses by both syngeneic and allogeneic
nonresponder spleen cells is mediated by a molecule encoded by the H-2 gene
complex; and (e) both syngeneic and allogeneic nonresponder mice are
suppressed by purified GAT-TsF that lacks immunoreactive GAT.
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