The Journal of Experimental Medicine
BioLegend: Antibody Reagents
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Journal of Experimental Medicine, Vol 146, 1367-1379, Copyright © 1977 by Rockefeller University Press

ARTICLES

Genetic control of cell-mediated responsiveness to an AKR tumor- associated antigen: mapping of the locus involved to the I region of the H-2 complex

D Meruelo, B Deak and HO McDevitt

The role of H-2-linked genes in controlling resistance to murine leukemia viruses has been studied by measuring the cell-mediated immune response of F1 hybrid mice (between AKR and various C3H and C57BL/10 derived, H-2 congenic strains) to an AKR tumor cell line, BW5147. The studies have shown that the ability to generate a primary or secondary cell-mediated response to an AKR tumor cell antigenic determinant is under H-2 linked control. The locus determining CML responsiveness maps in the I-J subregion. Nonresponsiveness is associated with the H-2q/k and H-2b/k hybrid genotypes, whereas responsiveness is associated with the H-2k/k homozygous genotype. Nonresponsiveness may result from (a) dominant suppression; (b) recessive responsiveness; or (c) an alternate mechanism not yet understood. This type of control may be one of several H-2-associated mechanisms of defense against virus-induced neoplasms.
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