The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 146, 1138-1142, Copyright © 1977 by Rockefeller University Press

ARTICLES

Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers

JJ Mond, R Lieberman, JK Inman, DE Mosier and WE Paul

Mice with the CBA/N defect are unresponsive to the hapten phosphorylcholine (PC) even when presented on a variety of immunogenic carriers. Since these mice have the variable region gene for PC, their inability to respond may reflect deletion or suppression of the line of B lymphocytes which is responsible for the anti-PC response.
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