Eosinophils and resistance to Trichinella spiralis

doi:10.1084/jem.145.3.755

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Eosinophils and resistance to Trichinella spiralis

DI Grove, AA Mahmoud and KS Warren
Department of Medicine, Case Western Reserve University, University Hospitals, Cleveland, Ohio 44106.

Mice infected with Trichinella spiralis were depleted of eosinophils by repeated administration of rabbit anti-mouse eosinophil serum. There was no effect on the spontaneous expulsion of adult worms from the small intestines, but the numbers of larvae in the muscles were almost doubled. It is concluded that eosinophils contribute to resistance to the systemic phase of trichinosis.
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