The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 145, 450-454, Copyright © 1977 by Rockefeller University Press

ARTICLES

Histocompatibility antigens controlled by the I region of the murine H- 2 complex. II. K/D region compatibility is not required for I-region cell-mediated lymphocytotoxicity

J Klein, CL Chiang and V Hauptfeld

In the cell-mediated lymphocytotoxicity assay, A.TH effector cells sensitized to A.TL lymphocytes lyse not only A.B10.AQR effector cells lyse B10.BR and B10.BYR target cells in addition to B10.AQR cells. These findings indicate that for CML to occur across the IA region barrier, compatibility at K or D regions is not required.
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