The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 145, 163-174, Copyright © 1977 by Rockefeller University Press

ARTICLES

The in vitro effects of Bordetella pertussis lymphocytosis-promoting factor on murine lymphocytes: II. Nature of the responding cells

AS Kong and SI Morse

The mitogenic response of murine lymphocytes to the lymphocytosis- promoting factor of Bordetella pertussis has been shown to be due to activation of T cells. The selectivity of responsiveness to LPF with respect to the population of T cells which is stimllated, differs from that of PHA as well as Con A, and the surface receptors are different. A population of adherent cells, which does not appear to consist of macrophages or other phagocytic cells, is required for the T-cell response.
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