The Journal of Experimental Medicine
StemCell Technologies
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Journal of Experimental Medicine, Vol 144, 1683-1688, Copyright © 1976 by Rockefeller University Press

ARTICLES

Spontaneous redistribution of surface immunoglobulin in the motile B lymphocyte

GF Schreiner, J Braun and ER Unanue

This paper reports that B cells undergoing translatory motion spontaneously segregate their surface Ig to one portion of their plasma membrane. The spontaneous redistribution of surface Ig was found to be: (a) selective, concanavalin A-dependent on translatory motion and energy metabolism. Abundant B cells undergoing motility were found after cultures in lipopolysaccharide or trypsin, or after brief exposure to cholinergic drugs.
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