Journal of Experimental Medicine, Vol 144, 1520-1530, Copyright © 1976 by Rockefeller University Press
Identification of a subpopulation of lymphocytes in human peripheral blood cytotoxic to autologous fibroblasts
R Parkman and FS Rosen
A naturally occurring subpopulation of human peripheral blood lymphocytes
is cytotoxic to autologous and/or allogeneic fibroblasts. The autocytotoxic
lymphocytes have a receptor for the third component of complement and for
aggregated gamma globulin, do not form rosettes with sheep red blood cells,
and are not removed by passage through nylon. The autocytotoxic
subpopulation is not present in the thymus and tonsils of normal children
or in the peripheral blood of individuals with X-linked agammaglobulinemia.
Fibroblast absorption experiments demonstrate that the autocytotoxic cells
are "sensitized" to antigens expressed on allogeneic fibroblasts in
addition to the antigens expressed on autologous cells. Some normal
individuals have a second subpopulation of lymphocytes that may "regulate"
the autocytotoxic cells. The relevance of these observations to the murine
autocytotoxic cells is discussed.
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