Journal of Experimental Medicine, Vol 144, 1031-1036, Copyright © 1976 by Rockefeller University Press
Induction of IgG in young nude mice by lipid A or thymus grafts
C Kolb, R Di Pauli and E Weiler
Postnatal serum concentrations of IgG2a of paternal allotype, measured in
congenitally thymusless nude mice, increase with kinetics and titers
comparable to their normal congeneic counterparts. Lipid A, the mitogenic
part of LPS, stimulates IgG synthesis in nude mice when it is given 7 days
after birth. IgG concentrations at 15 days of age are 6- to 8-fold higher
than in untreated control nudes; this is considerably lower, however, than
in normal mice, which show up to 45-fold higher IgG2ab levels after lipid A
treatment. A thymus graft from nearly congeneic donors of the same age,
transplanted at 4 days after birth, also stimulates long-lasting IgG
synthesis in the nude recipients. If the grafted nudes are injected with
lipid A 3 days later, IgG synthesis is further stimulated 8- to 16-fold.
The data are discussed in relation to the thymus dependency of IgG
production and the conditions for lipid A stimulation.
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