The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 144, 847-851, Copyright © 1976 by Rockefeller University Press

ARTICLES

Secretion of Ia antigens by a subpopulation of T cells which are Ly-1+, Ly-2-, and Ia-

IF McKenzie and CR Parish

It was found that Ia antignes are rapidly secreted by a subpopulation of splenic T lymphocytes which are nonadherent and which express the surface phenotype Ly-1+, Ly-2-, and Ia-. Secretion of the Ia antigens was a metabolically active process which was inhibited by sodium azide and by Pactamycin, an inhibitor of protein synthesis.
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