The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 143, 1042-1054, Copyright © 1976 by Rockefeller University Press

ARTICLES

Lymphocyte transformation induced by autologous cells. IV. Human T- lymphocyte proliferation induced by autologous or allogeneic non-T lymphocytes

MM Kuntz, JB Innes and ME Weksler

An autologous mixed lymphocyte reaction was demonstrated between T and non-T lymphocytes. Sheep erythrocyte rosetting was used to separate human lymphocytes into T and non-T lymphoid preparations. Non-T lymphocytes stimulated the proliferation of autologous T lymphocytes. The cell in this preparation that was most stimulatory had the characteristics of a K lymphocyte. The allogeneic mixed lymphocyte reaction was also shown to reflect the proliferation of T lymphocytes stimulated by allogeneic non-T lymphocytes. Proliferation of T lymphocytes in the allogeneic mixed lymphocyte culture probably reflects a response to both foreign histocompatibility determinants and determinants present on non-T lymphocytes. It is suggested that the proliferative response of T lymphocytes to autologous non-T lymphocytes may be a step in the process by which T lymphocytes regulate immunity.
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