Journal of Experimental Medicine, Vol 143, 450-455, Copyright © 1976 by Rockefeller University Press

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A single genetic element in H-2K affects mouse T-cell antiviral function in poxvirus infection

U Kees and RV Blanden

Cell transfer experiments using mice with recombinant H-2 haplotypes were used to map the H-2 regions which must be shared by ectromelia- immune T-cell donors and virus-infected recipients for transfer of virus clearance mechanisms in the spleen. K- or D-region genes were necessary and sufficient; I-region genes were not involved. The remainder of the mouse genome could be varied widely without impairing the efficacy of T-cell antiviral function, provided either a K or a D region was shared in the donor-receipient combination. A mutation in a single genetic element of the K region of the H-2 complex abolished the antiviral effect of immune T-cell transfer in a donor-recipient combination which shared the K end.
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• Snyder, J. T., Belyakov, I. M., Dzutsev, A., Lemonnier, F., Berzofsky, J. A. (2004). Protection against Lethal Vaccinia Virus Challenge in HLA-A2 Transgenic Mice by Immunization with a Single CD8+ T-Cell Peptide Epitope of Vaccinia and Variola Viruses. J. Virol. 78: 7052-7060 [Abstract] [Full Text]  

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