The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 142, 1564-1569, Copyright © 1975 by Rockefeller University Press

ARTICLES

Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control

S Britton

Experimental amyloidosis in mice can be induced by repeated injections of casein. It has now been demonstrated that casein induces strong polyclonal antibody synthesis in mouse B spleen lymphocytes. This effect is much more pronounced in spleen cells from anyloid-susceptible mice (CBA/J) than amyloid-resistant mice (A/J). It is suggested that amyloidosis can be due in some instances to a constant exposure for molecules which induce polyclonal B-cell activation.
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