H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T- cell specificities are associated with structures coded for in H-2K or H-2D;

doi:10.1084/jem.141.6.1427

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H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T- cell specificities are associated with structures coded for in H-2K or H-2D;

RM Zinkernagel and PC Doherty

Use of syngeneic, allogeneic, F1, AND H-2 recombinatn mice has shown that animals injected with lymphocytic choriomeningitis (LCM) virus generate T cells which are cytotoxic for H-2K or H-2D compatible, but not H-2 different, virus-infected target cells. Three separate lines of evidence are presented which indicate that these immune T cells are sensitized to "altered-self," the self antigens involved being coded for in the H-2K or H-2d regions. Firstly, cytotoxic activity associated with mutuality at H-2D iy, lysis mediated by immune T cells from F1 or H-2 recombinant mice is specifically inhibited only by presence of unlabeled, virus-infected cells that are H-2 compatible with the targets. Thirdly, LCM-immune F1 and H-2 recombinant T cells inoculated into irradiated, virus-infected recipients proliferate only to kill target cells that are H-2 compatible with both the donor and the recipient. All of these experiments establish that there is a dissociation of T-cell activities between parental haplotypes in F1 mice, and between H-2K and H-2D in recombinants. It would thus seem that there are at least two specificities of tlcm-immune T cells in homozygotes, associated with either H-2K or H-2D, and four specificities in F1 hybrids. The significance of these findings, with respect both to gene duplication and to the marked polymorphism in the H-2 system, is discussed.
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Ulmer, J., Donnelly, J., Parker, S., Rhodes, G., Felgner, P., Dwarki, V., Gromkowski, S., Deck, R., DeWitt, C., Friedman, A, et, al. (1993). Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259: 1745-1749 [Abstract]
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Meuer, S., Hussey, R., Hodgdon, J., Hercend, T, Schlossman, S., Reinherz, E. (1982). Surface structures involved in target recognition by human cytotoxic T lymphocytes. Science 218: 471-473 [Abstract]
Benacerraf, B (1981). Role of MHC gene products in immune regulation. Science 212: 1229-1238
Paul, W., Benacerraf, B (1977). Functional specificity of thymus- dependent lymphocytes. Science 195: 1293-1300 [Abstract]
Martin, W., Gipson, T., Martin, S., Rice, J. (1976). Derepressed alloantigen in transplacentally induced lung tumor coded for by H-2 linked gene. Science 194: 532-533 [Abstract]
Talmage, D., Dart, G, Radovich, J, Lafferty, K. (1976). Activation of transplant immunity: effect of donor leukocytes on thyroid allograft rejection. Science 191: 385-388 [Abstract]