Journal of Experimental Medicine, Vol 141, 1390-1399, Copyright © 1975 by Rockefeller University Press

ARTICLES

Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity

H Cantor and EA Boyse

Lymphocytes from BALB/c or C57B6/6 mice that develop killer activity to alloantigens belong to the numerically small Ly-23 subclass of peripheral T cells, distinguished by selective expression of Ly-23 determinants on their surfaces. The maturation of these cells to killer cells can be amplified by Ly-1+ cells, which do not themselves contribute to the killer cell pool. This amplification was abolished by escluding Ia("Beta")+ cells from the stimulator population during mixed lymphocyte culture (MCL), suggesting that amplification is due to selective recognition of I region antigens by L-1+ cells, a conclusion already drawn from our previous evidence that Ia differences activate Ly-1+ cells but not Ly-23+ cells. These and other experiments indicate that amplification of killer cell production in vitro by Ly-1+ cells is not due to their conversion to Ly-23+ cells during MLC, but to their ability to recognize major histocompatibility complex determinants not recognized by Ly-23+ cells.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Chess, L. (2006). The Birth of Functionally Distinct T Cell Subsets. J. Immunol. 176: 3859-3860 [Full Text]  
• Min, C.-K., Maeda, Y., Lowler, K., Liu, C., Clouthier, S., Lofthus, D., Weisiger, E., Ferrara, J. L. M., Reddy, P. (2004). Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T-cell subsets after experimental allogeneic bone marrow transplantation. Blood 104: 3393-3399 [Abstract] [Full Text]  
• Xu, H., Exner, B. G., Chilton, P. M., Schanie, C., Ildstad, S. T. (2004). CD45 Congenic Bone Marrow Transplantation: Evidence for T Cell-Mediated Immunity. Stem Cells 22: 1039-1048 [Abstract] [Full Text]  
• Deenick, E. K., Gett, A. V., Hodgkin, P. D. (2003). Stochastic Model of T Cell Proliferation: A Calculus Revealing IL-2 Regulation of Precursor Frequencies, Cell Cycle Time, and Survival. J. Immunol. 170: 4963-4972 [Abstract] [Full Text]  
• Xu, H., Exner, B. G., Cramer, D. E., Tanner, M. K., Mueller, Y. M., Ildstad, S. T. (2002). CD8+, {alpha}{beta}-TCR+, and {gamma}{delta}-TCR+ Cells in the Recipient Hematopoietic Environment Mediate Resistance to Engraftment of Allogeneic Donor Bone Marrow. J. Immunol. 168: 1636-1643 [Abstract] [Full Text]  
• Liu, X., Bai, X.-F., Wen, J., Gao, J.-X., Liu, J., Lu, P., Wang, Y., Zheng, P., Liu, Y. (2001). B7H Costimulates Clonal Expansion of, and Cognate Destruction of Tumor Cells by, CD8+ T Lymphocytes In Vivo. J. Exp. Med. 194: 1339-1348 [Abstract] [Full Text]  
• Hoft, D. F., Schnapp, A. R., Eickhoff, C. S., Roodman, S. T. (2000). Involvement of CD4+ Th1 Cells in Systemic Immunity Protective against Primary and Secondary Challenges with Trypanosoma cruzi. Infect. Immun. 68: 197-204 [Abstract] [Full Text]  
• Townsend, S., Allison, J. (1993). Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science 259: 368-370 [Abstract]  
• Benacerraf, B (1981). Role of MHC gene products in immune regulation. Science 212: 1229-1238  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS