The Journal of Experimental Medicine, Vol 140, 1660-1675,
Copyright © 1974 by The Rockefeller University Press
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO POLY-L(TYR,GLU)-POLY-D,L-ALA--POLY-L-LYS IN C3H
CWB TETRAPARENTAL MICE
Kathleen B. Bechtol 1,
John H. Freed 1,
Leonard A. Herzenberg 1, and
Hugh O. McDevitt 1
1 From the Division of Immunology, the Department of Medicine, and the Department of Genetics, Stanford University School of Medicine, Stanford, California 94305
In order to further delineate the mechanisms underlying genetic unresponsiveness, tetraparental mice were constructed from immune response-1A gene high responder and low responder parental genotypes, then were immunized with poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys ((T,G)-A--L). An analysis of the total serum allotype mixture and of the antigen-binding capacity of the separated allotypes demonstrated that in the milieu of a tetraparental mouse, both high and low responder B cells could be stimulated equally to produce identical high titered anti-(T,G)-A--L responses. Furthermore, these studies show that effective stimulation could occur across a histocompatibility disparity.
Submitted on August 28, 1974
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