The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 140, 1317-1323, Copyright © 1974 by The Rockefeller University Press

ARTICLE

I-REGION GENES ARE EXPRESSED ON T AND B LYMPHOCYTES : Studies of the Mixed Lymphocyte Reaction (MLR)



Peter Lonai 1 and Hugh O. McDevitt 1

1 From the Division of Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305

Unidirectional mixed lymphocyte reactions (MLR) were performed between mouse strains differing for various segments within the H-2 complex. Thymocytes and purified lymph node T cells and B cells were used as stimulator cells. In three of five combinations studied, differing only within the I region, both T and B cells stimulated in the MLR. This suggests that the region codes for both T- and B-cell surface structures. However, if the difference was restricted to one I subregion (I-C), only T cells stimulated. This finding suggests that some of the I-region genes may be expressed either in T or in B cells.

Submitted on July 15, 1974


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