The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 140, 1127-1132, Copyright © 1974 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

SEROLOGICAL DISTINCTION OF MUTANTS B6.C-H(z1) AND B6.M505 FROM STRAIN C57BL/6

Jan Klein 1, Miroslav Hauptfeld 1, and Vecaronra Hauptfeld 1

1 From the Department of Microbiology, The University of Texas Southwestern Medical School, Dallas, Texas 75235

A quantitative serological difference was found between strains Hz1 and M505 carrying mutant H-2 haplotypes ba and bd, respectively, and the original strain B6(H-2b). The finding suggests that the mutations occurred in the H-2Kb gene, and together with data on MLR and CML challenges the current concept of H-2 regions' involvement in immune reactions.

Submitted on July 23, 1974


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