The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 140, 591-596, Copyright © 1974 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

QUANTITATIVE STUDIES ON TUMOR ENHANCEMENT IN MICE : I. ENHANCEMENT OF SARCOMA I INDUCED BY IgM, IgG1, AND IgG2



Pablo Rubinstein 1, Francine Decary 1, and Edwin W. Streun 1

1 From the Laboratory of Serology and Genetics, The New York Blood Center, New York 10021, and the Department of Pathology, Mt. Sinai School of Medicine, City University of New York, New York 10029

The concentration of specific alloantibody in purified mouse immunoglobulin preparations was determined. When passively transferred in adequate doses, IgM, IgG1, and IgG2 antibodies all induced tumor enhancement in allogeneic hosts. IgM and IgG2 antibodies in high concentration led to inhibition of tumor growth. IgM and either IgG1 or IgG2 had additive effects on tumor enhancement. IgG1, but not IgG2, suppressed the inhibitory effect of IgM in high concentration.

Submitted on April 30, 1974


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