IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE: III. FUNCTIONAL PROPERTIES IN VIVO

doi:10.1084/jem.139.6.1431

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ARTICLE

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE : III. FUNCTIONAL PROPERTIES IN VIVO

Ralph M. Steinman ¹, Dinah S. Lustig ¹, and Zanvil A. Cohn ¹

¹ From The Rockefeller University, New York 10021

Several properties of lymphoid dendritic cells in situ havebeen determined, and contrasted to information previously establishedfor lymphocytes and mononuclear phagocytes. Dendritic cellsare not found in newborn mice, and their concentration in bothspleen and mesenteric lymph node does not reach adult levelsuntil 3–4 wk of age. Dendritic cells largely disappearfrom adherent populations following administration of steroids(2.5 mg hydrocortisone acetate s.c.) and ionizing radiation(D_o of 100 rads for Co⁶⁰). Splenic dendritic cells can originatefrom precursors located in both bone marrow and spleen itself,probably the red pulp. The mature splenic population does notactively divide (pulse labeling index with [³H]thymidineof 1.5–2.5%), but does turnover at substantial rate, 10+%of the total pool per day. The influx of new cells appears tobe derived from a proliferating precursor compartment, but themechanism for efflux or turnover is not known. Dendritic cellsin spleen and node undergo little or moderate increase in numbersduring development of a primary immune response. These in vivocharacteristics, taken together, further distinguish dendriticcells as a novel cell type, distinct from mononuclear phagocytesand lymphocytes.

Submitted on February 15, 1974

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