The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 139, 1382-1394, Copyright © 1974 by The Rockefeller University Press

ARTICLE

INDUCTION OF PARTIAL IMMUNOLOGIC TOLERANCE IN RATS AND PROGRESSIVE LOSS OF CELLULAR ANTIGENICITY IN GROSS VIRUS LYMPHOMA

Harry L. Ioachim 1, Steven E. Keller 1, Brent H. Dorsett 1, and Antonia Pearse 1

1 From the Departments of Pathology of Lenox Hill Hospital and the College of Physicians and Surgeons of Columbia University, New York 10021

Gross virus-induced lymphoma cells express strong virus-associated (Gross murine leukemia virus [G-MuLV]) antigens and are consistently rejected when grafted in normal adult syngeneic rats. By contrast, similar grafts are tolerated and allowed to grow progressively by rats that have been injected at birth with deaggregated G-MuLV antigens. However, the tolerance induced by this procedure is only partial as the grafted lymphoma cells lose their G-MuLV membrane antigens. These cells showing an antigenic disjunction, with negative membrane and positive cytoplasmic G-MuLV antigenic expression, become transplantable in normal-nonconditioned adult recipients. By further grafting, the expression of cytoplasmic G-MuLV antigens is similarly lost while the lymphoma cells substantially increase their transplantability, rate of growth, and capacity for metastasis.

Submitted on January 21, 1974


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