The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 139, 1262-1282, Copyright © 1974 by The Rockefeller University Press

ARTICLE

CHANGES IN CELLULAR ENZYME LEVELS AND EXTRACELLULAR RELEASE OF LYSOSOMAL ACID HYDROLASES IN MACROPHAGES EXPOSED TO GROUP A STREPTOCOCCAL CELL WALL SUBSTANCE

Philip Davies 1, Roy C. Page 1, and A. C. Allison 1

1 From the Division of Cell Pathology, Medical Research Council, Clinical Research Centre, Harrow, Middlesex HA1 3UJ, and the Departments of Pathology and Periodontics and the Center for Research in Oral Biology, University of Washington, Seattle, Washington 98105

Mouse peritoneal macrophages exposed to type-specific polysaccharide and peptidoglycan (PPG) from group A streptococci undergo marked morphologic and biochemical changes. The cells show increases in size and an increased number of lysosomes as demonstrated by vital staining with acridine orange. There are significant elevations in the levels of both lysosomal and nonlysosomal enzymes. Higher doses of PPG cause selective release of the hydrolases into the extracellular environment with no detectable loss of cell viability. The in vitro phenomena may be relevant to understanding the role of macrophages in chronic inflammation.

Submitted on November 11, 1973


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