The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 139, 925-942, Copyright © 1974 by The Rockefeller University Press

ARTICLE

COMMON CELL SURFACE ANTIGEN ASSOCIATED WITH MAMMALIAN C-TYPE RNA VIRUSES : CELL MEMBRANE-BOUND gs ANTIGEN



Takashi Yoshiki 1, Robert C. Mellors 1, William D. Hardy Jr. 1, and Erwin Fleissner 1

1 From The Hospital for Special Surgery, Affiliated with The New York Hospital-Cornell University Medical College and the Department of Pathology, Cornell University Medical College, New York, and the Laboratory of Veterinary Oncology, and, the Laboratory of Viral Oncology, Sloan-Kettering Institute for Cancer Research, New York

The indirect membrane immunofluorescence test and the absorption analysis of rabbit anti-FeLV, rabbit anti-FeLVp 30, and rabbit anti-MuLVp 30 antisera yielded the following conclusions. An antigen shared by mammalian (murine and feline) C-type RNA leukemia and sarcoma viruses was detected on the surface of cells infected or transformed by C-type viruses. The antigen was characterized as membrane-bound gs antigen bearing two determinants, membrane-bound gs-1, intraspecies-specific antigenic determinant, and membrane-bound gs-3, interspecies-specific antigenic determinant. Membrane-bound gs antigen was located on the cell surface, frequently near the site of virus budding but not on the envelope of murine C-type RNA virus.

Submitted on January 9, 1974


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