The Journal of Experimental Medicine, Vol 139, 851-861,
Copyright © 1974 by The Rockefeller University Press
MIXED LYMPHOCYTE CULTURE RESPONSES OF MICE
:
GENETIC ANALYSIS OF THE RESPONSES TO H-2Dd SPECIFICITIES
Janet M. D. Plate 1
1 From the Transplantation Unit, General Surgical Services and the Department of Surgery, Harvard Medical School, at the Massachusetts General Hospital, Boston, Massachusetts 02114
Cellular responses in vitro to H-2D region histocompatibility antigens were demonstrated to be under the genetic control of two or three (P = 0.013) independently segregating loci. The H-2 region itself accounts for one of these loci, however, its activity appears to be dependent upon an association with other non-H-2-associated genetic information. The ability to stimulate a response and to respond to that stimulus are two separate genetic functions in certain MLR combinations. The stimuli in our studies were products of the H-2D region and cell donors must differ at that region in order for a response to occur. The control of the level of responses was determined by other genetic material. Differences at these "response loci" were not necessary for the induction of a proliferative response in the mixed lymphocyte cultures.
Submitted on January 1, 1974
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
